Major trial finds statins may lower heart risks in healthy older adults
31 Aug 2026
The STAREE (Statins in Reducing Events in the Elderly) trial, led by researchers from Monash University, followed almost 10,000 participants across Australia for up to 10 years.
The study involved more than 3,400 GPs from over 1,000 general practices.
Participants were aged 70 or older, lived independently and had no previous cardiovascular disease, diabetes, dementia or other conditions expected to limit their lifespan.
A total of 9,971 people took part. Of these, 4,984 received 40 mg of atorvastatin each day, while 4,987 received a placebo.
Over an average follow-up of six years, people taking atorvastatin had a lower risk of major cardiovascular events than those taking the placebo.
Researchers said the trial provides important evidence about the use of statins in healthy older people, including those aged over 75.
The study is the first randomised controlled trial to specifically examine whether statins can provide cardiovascular benefits for healthy older adults without established cardiovascular disease.
Lead researcher Adjunct Professor Sophia Zoungas said the findings could influence how cardiovascular risk is managed in older people.
Professor Mark Nelson, a GP and study co-author, said the trial provided strong evidence from the specific age group being studied, rather than relying mainly on data from younger populations.
Researchers hope the results will contribute to updated treatment guidelines for older adults.
The decision to use statins for prevention remains a matter for discussion between doctors and their patients, taking into account the individual patient and their preferences.
Major trial finds statins may lower heart risks in healthy older adults
Source: New England Journal of Medicine — STAREE trial, Monash University.